作者
Donna L White, Ali Hashmi, David J Ramsey, Jill Kuzniarek, Shahriar Tavakoli-Tabasi, Hashem B El-Serag
发表日期
2012/11
期刊
Digestive diseases and sciences
卷号
57
页码范围
3004-3010
出版商
Springer US
简介
Aim
We evaluated the association between two medications that alter bioavailable androgen levels, finasteride and methadone, and risk of advanced HCV-related liver disease.
Background
Males have strikingly greater cirrhosis risk across disease etiologies, including hepatitis C virus (HCV) infection.
Methods
In a cross-sectional study in HCV+ male veterans, we determined medication use by up to 15-year medical record review, and hepatic pathology by the FibroSURE-ActiTest (F3/F4-F4, advanced vs. F0-F3, mild fibrosis; and A2/A3-A3, advanced vs. A0-A2, mild inflammation). We performed race-adjusted and race-stratified multivariate analyses.
Results
Among 571 HCV+ males, 43 % were White and 57 % African-American. There were non-significant decreased risks with …
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