作者
Hashem B El-Serag, Ali Hashmi, Jose Garcia, Peter Richardson, Abeer Alsarraj, Stephanie Fitzgerald, Marcelo Vela, Yasser Shaib, Neena S Abraham, Maria Velez, Rhonda Cole, Margot B Rodriguez, Bhupinderjit Anand, David Y Graham, Jennifer R Kramer
发表日期
2014/2/1
期刊
Gut
卷号
63
期号
2
页码范围
220-229
出版商
BMJ Publishing Group
简介
Objective
Abdominal obesity has been associated with increased risk of Barrett's oesophagus (BE) but the underlying mechanism is unclear. We examined the association between visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) and the risk of BE.
Design
A case-control study among eligible patients scheduled for elective oesophagastroduodenoscopy (EGD) and in a sample of patients eligible for screening colonoscopy recruited at the primary care clinic. All cases with definitive BE and a random sample of controls without BE were invited to undergo standardised mid-abdomen non-contrast computerised axial tomography images, which were analysed by semiautomated image segmentation software. The effect of VAT and SAT surface areas and their ratio (VAT to SAT) on BE were analysed in logistic regression models.
Results
A total of 173 BE cases, 343 colonoscopy controls and 172 …
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HB El-Serag, A Hashmi, J Garcia, P Richardson… - Gut, 2014