作者
Hideki Ueno, Eynav Klechevsky, Rimpei Morita, Caroline Aspord, Tinghua Cao, Toshimichi Matsui, Tiziana Di Pucchio, John Connolly, Joseph W Fay, Virginia Pascual, A Karolina Palucka, Jacques Banchereau
发表日期
2007/10
来源
Immunological reviews
卷号
219
期号
1
页码范围
118-142
出版商
Blackwell Publishing Ltd
简介
The dendritic cell (DC) system of antigen‐presenting cells controls immunity and tolerance. DCs initiate and regulate immune responses in a manner that depends on signals they receive from microbes and their cellular environment. They allow the immune system to make qualitatively distinct responses against different microbial infections. DCs are composed of subsets that express different microbial receptors and express different surface molecules and cytokines. Our studies lead us to propose that interstitial (dermal) DCs preferentially activate humoral immunity, whereas Langerhans cells preferentially induce cellular immunity. Alterations of the DC system result in diseases such as autoimmunity, allergy, and cancer. Conversely, DCs can be exploited for vaccination, and novel vaccines that directly target DCs in vivo are being designed.
引用总数
学术搜索中的文章
H Ueno, E Klechevsky, R Morita, C Aspord, T Cao… - Immunological reviews, 2007