作者
Hongjin Huang, Mitchell L Shiffman, Ramsey C Cheung, Thomas J Layden, Scott Friedman, Olivia T Abar, Linda Yee, Anand P Chokkalingam, Steven J Schrodi, Jason Chan, Joseph J Catanese, Diane U Leong, David Ross, Xiaolan Hu, Alexander Monto, Linda B McAllister, Samuel Broder, Thomas White, John J Sninsky, Teresa L Wright
发表日期
2006/5/1
期刊
Gastroenterology
卷号
130
期号
6
页码范围
1679-1687
出版商
WB Saunders
简介
Background & Aims
Previously identified clinical risk factors such as sex, alcohol consumption, and age at infection do not accurately predict which patients with chronic hepatitis C (CHC) will develop advanced fibrosis (bridging fibrosis and cirrhosis). The aim of this study was to identify genetic polymorphisms that can predict the risk of advanced fibrosis in patients with CHC.
Methods
A total of 916 subjects with CHC was enrolled from 2 centers. A gene-centric disease association study of 24,832 putative functional, single nucleotide polymorphisms (SNPs) was performed. Of the 1609 SNPs that were significantly associated (P ≤ .05) with advanced fibrosis in the discovery cohort (University of California San Francisco [UCSF], N = 433), the first batch of 100 SNPs were selected for validation in the replication cohort (Virginia Commonwealth University [VCU], N = 483).
Results
A missense SNP in the DEAD box …
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