作者
Larissa Fabritz, Eduard Guasch, Charalambos Antoniades, Isabel Bardinet, Gerlinde Benninger, Tim R Betts, Eva Brand, Guenter Breithardt, Gabriela Bucklar-Suchankova, A John Camm, David Cartlidge, Barbara Casadei, Winnie WL Chua, Harry JGM Crijns, Jon Deeks, Stephane Hatem, Francoise Hidden-Lucet, Stefan Kaeaeb, Nikos Maniadakis, Stephan Martin, Lluis Mont, Holger Reinecke, Moritz F Sinner, Ulrich Schotten, Taunton Southwood, Monika Stoll, Panos Vardas, Reza Wakili, Andy West, Andre Ziegler, Paulus Kirchhof
发表日期
2016/4
来源
Nature Reviews Cardiology
卷号
13
期号
4
页码范围
230-237
出版商
Nature Publishing Group UK
简介
Despite remarkable advances in antiarrhythmic drugs, ablation procedures, and stroke-prevention strategies, atrial fibrillation (AF) remains an important cause of death and disability in middle-aged and elderly individuals. Unstructured management of patients with AF sharply contrasts with our detailed, although incomplete, knowledge of the mechanisms that cause AF and its complications. Altered calcium homeostasis, atrial fibrosis and ageing, ion-channel dysfunction, autonomic imbalance, fat-cell infiltration, and oxidative stress, in addition to a susceptible genetic background, contribute to the promotion, maintenance, and progression of AF. However, clinical management of patients with AF is currently guided by stroke risk parameters, AF pattern, and symptoms. In response to this apparent disconnect between the known pathophysiology of AF and clinical management, we propose a roadmap to develop a set …
学术搜索中的文章
L Fabritz, E Guasch, C Antoniades, I Bardinet… - Nature Reviews Cardiology, 2016