作者
R Daniel Kortschak, Philip W Tucker, Robert Saint
发表日期
2000/6/1
来源
Trends in biochemical sciences
卷号
25
期号
6
页码范围
294-299
出版商
Elsevier
简介
Members of the recently discovered ARID (AT-rich interaction domain) family of DNA-binding proteins are found in fungi and invertebrate and vertebrate metazoans. ARID-encoding genes are involved in a variety of biological processes including embryonic development, cell lineage gene regulation and cell cycle control. Although the specific roles of this domain and of ARID-containing proteins in transcriptional regulation are yet to be elucidated, they include both positive and negative transcriptional regulation and a likely involvement in the modification of chromatin structure.
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RD Kortschak, PW Tucker, R Saint - Trends in biochemical sciences, 2000