作者
Ajaz A Bhat, Salma N Younes, Syed Shadab Raza, Lubna Zarif, Sabah Nisar, Ikhlak Ahmed, Rashid Mir, Sachin Kumar, Surender K Sharawat, Sheema Hashem, Imadeldin Elfaki, Michal Kulinski, Shilpa Kuttikrishnan, Kirti S Prabhu, Abdul Q Khan, Santosh K Yadav, Wael El-Rifai, Mohammad A Zargar, Hatem Zayed, Mohammad Haris, Shahab Uddin
发表日期
2020/12
来源
Molecular cancer
卷号
19
页码范围
1-21
出版商
BioMed Central
简介
Early-stage detection of leukemia is a critical determinant for successful treatment of the disease and can increase the survival rate of leukemia patients. The factors limiting the current screening approaches to leukemia include low sensitivity and specificity, high costs, and a low participation rate. An approach based on novel and innovative biomarkers with high accuracy from peripheral blood offers a comfortable and appealing alternative to patients, potentially leading to a higher participation rate.
Recently, non-coding RNAs due to their involvement in vital oncogenic processes such as differentiation, proliferation, migration, angiogenesis and apoptosis have attracted much attention as potential diagnostic and prognostic biomarkers in leukemia. Emerging lines of evidence have shown that the mutational spectrum and dysregulated expression of non-coding RNA genes are closely associated with …
学术搜索中的文章
AA Bhat, SN Younes, SS Raza, L Zarif, S Nisar… - Molecular cancer, 2020