作者
Vivek J Srinivasan, Esther Yu, Harsha Radhakrishnan, Anil Can, Mihail Climov, Conor Leahy, Cenk Ayata, Katharina Eikermann-Haerter
发表日期
2015/10
期刊
Journal of Cerebral Blood Flow & Metabolism
卷号
35
期号
10
页码范围
1552-1560
出版商
SAGE Publications
简介
Although microvascular dysfunction accompanies cognitive decline in aging, vascular dementia, and Alzheimer's disease, tools to study microvasculature longitudinally in vivo are lacking. Here, we use Doppler optical coherence tomography (OCT) and angiography for noninvasive, longitudinal imaging of mice with chronic cerebral hypoperfusion for up to 1 month. In particular, we optimized the OCT angiography method to selectively image red blood cell (RBC)-perfused capillaries, leading to a novel way of assessing capillary supply heterogeneity in vivo. After bilateral common carotid artery stenosis (BCAS), cortical blood flow measured by Doppler OCT dropped to half of baseline throughout the imaged tissue acutely. Microscopic imaging of the capillary bed with OCT angiography further revealed local heterogeneities in cortical flow supply during hypoperfusion. The number of RBC-perfused capillaries …
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VJ Srinivasan, E Yu, H Radhakrishnan, A Can… - Journal of Cerebral Blood Flow & Metabolism, 2015