作者
Ben Tran, Scott Kopetz, Jeanne Tie, Peter Gibbs, Zhi‐Qin Jiang, Christopher H Lieu, Atin Agarwal, Dipen M Maru, Oliver Sieber, Jayesh Desai
发表日期
2011/10/15
期刊
Cancer
卷号
117
期号
20
页码范围
4623-4632
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
BACKGROUND
It is hypothesized that BRAF mutant cancers represent a discrete subset of metastatic colorectal cancer (CRC) defined by poorer survival. This study investigates whether BRAF mutant CRC is further defined by a distinct pattern of metastatic spread and explores the impact of BRAF mutation and microsatellite instability (MSI) on prognosis in metastatic CRC.
METHODS
By using prospective clinical data and molecular analyses from 2 major centers (Royal Melbourne Hospital and The University of Texas MD Anderson Cancer Center), patients with known BRAF mutation status were analyzed for clinical characteristics, survival, and metastatic sites.
RESULTS
The authors identified 524 metastatic CRC patients where BRAF mutation status was known; 57 (11%) were BRAF mutant tumors. BRAF mutant tumors were significantly associated with right‐sided primary tumor, MSI, and poorer survival …
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B Tran, S Kopetz, J Tie, P Gibbs, ZQ Jiang, CH Lieu… - Cancer, 2011