作者
Robert N Jorissen, Peter Gibbs, Michael Christie, Saurabh Prakash, Lara Lipton, Jayesh Desai, David Kerr, Lauri A Aaltonen, Diego Arango, Mogens Kruhøffer, Torben F Ørntoft, Claus Lindbjerg Andersen, Mike Gruidl, Vidya P Kamath, Steven Eschrich, Timothy J Yeatman, Oliver M Sieber
发表日期
2009/12/15
期刊
Clinical Cancer Research
卷号
15
期号
24
页码范围
7642-7651
出版商
American Association for Cancer Research
简介
Purpose: Colorectal cancer prognosis is currently predicted from pathologic staging, providing limited discrimination for Dukes stage B and C disease. Additional markers for outcome are required to help guide therapy selection for individual patients.
Experimental Design: A multisite single-platform microarray study was done on 553 colorectal cancers. Gene expression changes were identified between stage A and D tumors (three training sets) and assessed as a prognosis signature in stage B and C tumors (independent test and external validation sets).
Results: One hundred twenty-eight genes showed reproducible expression changes between three sets of stage A and D cancers. Using consistent genes, stage B and C cancers clustered into two groups resembling early-stage and metastatic tumors. A Prediction Analysis of Microarray algorithm was developed to classify …
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RN Jorissen, P Gibbs, M Christie, S Prakash, L Lipton… - Clinical Cancer Research, 2009