作者
Augusto Di Castelnuovo, Simona Costanzo, Andrea Antinori, Nausicaa Berselli, Lorenzo Blandi, Marialaura Bonaccio, Roberto Cauda, Giovanni Guaraldi, Lorenzo Menicanti, Marco Mennuni, Giustino Parruti, Giuseppe Patti, Francesca Santilli, Carlo Signorelli, Alessandra Vergori, Pasquale Abete, Walter Ageno, Antonella Agodi, Piergiuseppe Agostoni, Luca Aiello, Samir Al Moghazi, Rosa Arboretti, Marinella Astuto, Filippo Aucella, Greta Barbieri, Alessandro Bartoloni, Paolo Bonfanti, Francesco Cacciatore, Lucia Caiano, Laura Carrozzi, Antonio Cascio, Arturo Ciccullo, Antonella Cingolani, Francesco Cipollone, Claudia Colomba, Crizia Colombo, Francesca Crosta, Gian Battista Danzi, Damiano D'Ardes, Katleen de Gaetano Donati, Francesco Di Gennaro, Giuseppe Di Tano, Gianpiero D'Offizi, Massimo Fantoni, Francesco Maria Fusco, Ivan Gentile, Francesco Gianfagna, Elvira Grandone, Emauele Graziani, Leonardo Grisafi, Gabriella Guarnieri, Giovanni Larizza, Armando Leone, Gloria Maccagni, Ferruccio Madaro, Stefano Maitan, Sandro Mancarella, Massimo Mapelli, Riccardo Maragna, Rossella Marcucci, Giulio Maresca, Silvia Marongiu, Claudia Marotta, Lorenzo Marra, Franco Mastroianni, Maria Mazzitelli, Alessandro Mengozzi, Francesco Menichetti, Marianna Meschiari, Jovana Milic, Filippo Minutolo, Beatrice Molena, Arturo Montineri, Cristina Mussini, Maria Musso, Daniela Niola, Anna Odone, Marco Olivieri, Antonella Palimodde, Roberta Parisi, Emanuela Pasi, Raffaele Pesavento, Francesco Petri, Biagio Pinchera, Venerino Poletti, Claudia Ravaglia, Andrea Rognoni, Marco Rossato, Marianna Rossi, Vincenzo Sangiovanni, Carlo Sanrocco, Laura Scorzolini, Raffaella Sgariglia, Paola Giustina Simeone, Eleonora Taddei, Carlo Torti, Roberto Vettor, Andrea Vianello, Marco Vinceti, Alexandra Virano, Laura Vocciante, Raffaele De Caterina, Licia Iacoviello
发表日期
2021/8
期刊
Thrombosis and haemostasis
卷号
121
期号
08
页码范围
1054-1065
出版商
Georg Thieme Verlag KG
简介
Introduction A hypercoagulable condition was described in patients with coronavirus disease 2019 (COVID-19) and proposed as a possible pathogenic mechanism contributing to disease progression and lethality.
Aim We evaluated if in-hospital administration of heparin improved survival in a large cohort of Italian COVID-19 patients.
Methods In a retrospective observational study, 2,574 unselected patients hospitalized in 30 clinical centers in Italy from February 19, 2020 to June 5, 2020 with laboratory-confirmed severe acute respiratory syndrome coronavirus-2 infection were analyzed. The primary endpoint in a time-to event analysis was in-hospital death, comparing patients who received heparin (low-molecular-weight heparin [LMWH] or unfractionated heparin [UFH]) with patients who did not. We used multivariable Cox proportional-hazards regression models with inverse probability for treatment …
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A Di Castelnuovo, S Costanzo, A Antinori, N Berselli… - Thrombosis and haemostasis, 2021