作者
João Pedro Ferrari‐Souza, Bruna Bellaver, Pamela CL Ferreira, Guilherme Povala, Firoza Z Lussier, Douglas Teixeira Leffa, Joseph Therriault, Cécile Tissot, Andrea Lessa Benedet, Carolina Soares, Cristiano Schaffer Aguzzoli, Hussein Zalzale, Francieli Rohden, Yi‐Ting Wang, Mira Chamoun, Stijn Servaes, Arthur C Macedo, Marie Vermeiren, Gleb Bezgin, Min Su Kang, Jenna Stevenson, Nesrine Rahmouni, Vanessa Pallen, Nina Margherita Poltronetti, Diogo O Souza, Jean‐Paul Soucy, Serge Gauthier, Gallen Triana‐Baltzer, Ziad S Saad, Hartmuth C Kolb, Lucas Porcello Schilling, Thomas K Karikari, Nicholas J Ashton, Henrik Zetterberg, Kaj Blennow, Pedro Rosa‐Neto, Tharick A Pascoal, Eduardo R Zimmer
发表日期
2023/12
期刊
Alzheimer's & Dementia
卷号
19
页码范围
e078423
简介
Background
Glial contributions to Alzheimer’s disease (AD) etiology and progression have been increasingly recognized. Experimental and clinical evidence suggests that both microglial activation and astrocyte reactivity have pivotal roles in the progression of tau pathology. However, it remains to be elucidated how microglia and astrocytes complement each other in AD pathogenesis. Here, we tested the associations between reactive astrogliosis and microglial activation with tau phosphorylation and aggregation in individuals across the aging and AD spectrum.
Method
We studied 95 participants (14 cognitively unimpaired [CU] young, 46 CU elderly, and 35 cognitively impaired [CI]) from the Translational Biomarkers in Aging and Dementia (TRIAD) cohort. Individuals had available positron emission tomography (PET) for Aβ ([18F]AZD4694), tau tangles ([18F]MK6240), and microglial activation ([11C]PBR28 …
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JP Ferrari‐Souza, B Bellaver, PCL Ferreira, G Povala… - Alzheimer's & Dementia, 2023