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We assessed seasonal histological changes as markers of health status in mussels Mytilus spp. sampled from Southampton Water, Hampshire, UK and the River Exe, Devon, UK between November 2004 and October 2005. A total of 29 health parameters related to pathogens, inflammatory and non-specific pathologies, and reproductive and physiological condition were recorded monthly from individual mussels collected from these 2 sites. We then assessed the diffential prevalence of these health parameters according to species. M. edulis, M. galloprovincialis and their hybrids were identified using the Glu-5’gene and the ME15 and ME16 primer sets that distinguish alleles specific to M. edulis (180 bp), M. galloprovincialis (126 bp) and hybrids (180 bp/126 bp). Although no overall annual differences were observed between species with respect to median levels of adipogranular (ADG) tissue and reproductive …