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Cotton production is highly vulnerable to climate change, and heat stress is a major constraint in the cotton zone of Punjab, Pakistan. Adaptation is perceived as a critical step to deal with forecasted and unexpected climatic conditions. The objective of this study was to standardize and authenticate a cotton crop model based on climate and crop husbandry data in order to develop an adaptation package for cotton crop production in the wake of climate change. For the study, the data were collected from the cotton-growing areas of Punjab, viz. Bahawalpur and Khanewal. After the calibration and validation against field data, the Cropping System Model CSM–CROPGRO–Cotton in the shell of the decision support system for agro-technology transfer (DSSAT) was run with a future climate generated under two representative concentrations pathways (RCPs), viz. RCPs 4.5 and 8.5 with five global circulation models (GCMs). The whole study showed that a model is an artistic tool for examining the temporal variation in cotton and determining the potential impact of planting dates on crop growth, phenology, and yield. The results showed that the future climate would have drastic effects on cotton production in the project area. Reduction in seed cotton yield (SCY) was 25.7% and 32.2% under RCPs 4.5 and 8.5, respectively. The comparison of five GCMs showed that a hot/wet climate would be more damaging than other scenarios. The simulations with different production options showed that a 10% and 5% increase in nitrogen and plant population, respectively, compared to the present would be the best strategy in the future. The model further suggested …