作者
Frederika A Van Nimwegen, John Penders, Ellen E Stobberingh, Dirkje S Postma, Gerard H Koppelman, Marjan Kerkhof, Naomi E Reijmerink, Edward Dompeling, Piet A Van Den Brandt, Isabel Ferreira, Monique Mommers, Carel Thijs
发表日期
2011/11/1
期刊
Journal of Allergy and Clinical Immunology
卷号
128
期号
5
页码范围
948-955. e3
出版商
Mosby
简介
BACKGROUND
Both gastrointestinal microbiota composition and cesarean section have been linked to atopic manifestations. However, results are inconsistent, and the hypothesized intermediate role of the microbiota in the association between birth mode and atopic manifestations has not been studied yet.
OBJECTIVES
We sought to investigate the relationship between microbiota composition, mode and place of delivery, and atopic manifestations.
METHODS
The Child, Parent and Health: Lifestyle and Genetic Constitution Birth Cohort Study included data on birth characteristics, lifestyle factors, and atopic manifestations collected through repeated questionnaires from birth until age 7 years. Fecal samples were collected at age 1 month (n = 1176) to determine microbiota composition, and blood samples were collected at ages 1 (n = 921), 2 (n = 822), and 6 to 7 (n = 384) years to determine specific IgE levels …
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FA Van Nimwegen, J Penders, EE Stobberingh… - Journal of Allergy and Clinical Immunology, 2011