作者
Ema Kavaliunaite, Kathryn A Harris, Paul Aurora, Garth Dixon, Delane Shingadia, Nagarajan Muthialu, Helen Spencer
发表日期
2020/6
期刊
Transplant infectious disease
卷号
22
期号
3
页码范围
e13274
简介
Background
Mycobacterium abscessus infection has been associated with variable outcomes following lung transplantation. M abscessus comprises three subspecies (M abscessus subsp abscessus, M abscessus subsp massiliense, and M abscessus subsp bolletii). We investigated whether lung transplantation outcome in cystic fibrosis (CF) patients in a single center was related to the M abscessus subspecies and genetic cluster.
Methods
CF patients with chronic M abscessus infection transplanted at Great Ormond Street Hospital between 2004 and 2017 were retrospectively examined. All M abscessus isolates were identified to subspecies level by polymerase chain reaction and sequencing. Genetic cluster was determined by variable number tandem repeat profiling and whole‐genome sequencing (WGS), and sequence type inferred from WGS.
Results
Thirteen patients with chronic M abscessus infection …
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E Kavaliunaite, KA Harris, P Aurora, G Dixon… - Transplant infectious disease, 2020