作者
Qi Feng, Aoshuang Zhou, Huachun Zou, Suzanne Ingle, Margaret T May, Weiping Cai, Chien-Yu Cheng, Zuyao Yang, Jinling Tang
发表日期
2019/7/8
来源
bmj
卷号
366
出版商
British Medical Journal Publishing Group
简介
Objective
To evaluate the effects of four drug (quadruple) versus three drug (triple) combination antiretroviral therapies in treatment naive people with HIV, and explore the implications of existing trials for clinical practice and research.
Design
Systematic review and meta-analysis of randomised controlled trials.
Data sources
PubMed, EMBASE, CENTRAL, Web of Science, and the Cumulative Index to Nursing and Allied Health Literature from March 2001 to December 2016 (updated search in PubMed and EMBASE up to June 2018); and reference lists of eligible studies and related reviews.
Study selection
Randomised controlled trials comparing quadruple with triple combination antiretroviral therapies in treatment naive people with HIV and evaluating at least one effectiveness or safety outcome.
Review methods
Outcomes of interest included undetectable HIV-1 RNA, CD4 T cell count, virological failure, new AIDS …
学术搜索中的文章
Q Feng, A Zhou, H Zou, S Ingle, MT May, W Cai… - bmj, 2019
