作者
JQ Yuan, KKF Tsoi, M Yang, JY Wang, DE Threapleton, ZY Yang, B Zou, C Mao, JL Tang, FKL Chan
发表日期
2016/6
来源
Alimentary pharmacology & therapeutics
卷号
43
期号
12
页码范围
1262-1275
简介
Background
Many strategies are used to prevent nonsteroidal anti‐inflammatory drug (NSAID)‐associated gastrointestinal toxicity, but the comparative effectiveness remains unclear.
Aim
To evaluate the comparative effectiveness of clinical strategies for preventing gastrointestinal toxicity induced by NSAIDs.
Methods
MEDLINE, EMBASE and the Cochrane Library (from their inception to May 2015) were searched for randomised controlled trials comparing the risk of gastrointestinal adverse events in patients taking nonselective NSAIDs, selective cyclooxygenase(COX)‐2 inhibitors or nonselective NSAIDs/COX‐2 inhibitors plus gastroprotective agents [proton pump inhibitors (PPIs), histamine‐2 receptor antagonists, misoprostol]. Both pairwise meta‐analysis and Bayesian network meta‐analysis were performed.
Results
Analyses were based on 82 trials including 125 053 participants. Network meta‐analysis …
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JQ Yuan, KKF Tsoi, M Yang, JY Wang, DE Threapleton… - Alimentary pharmacology & therapeutics, 2016