作者
Salim Kanoun, Cédric Rossi, Alina Berriolo-Riedinger, Inna Dygai-Cochet, Alexandre Cochet, Olivier Humbert, Michel Toubeau, Emmanuelle Ferrant, François Brunotte, René-Olivier Casasnovas
发表日期
2014/9
期刊
European journal of nuclear medicine and molecular imaging
卷号
41
页码范围
1735-1743
出版商
Springer Berlin Heidelberg
简介
Purpose
The presence of a bulky tumour at staging in Hodgkin lymphoma (HL) is a predictor of a poor outcome. The total metabolic tumour volume at baseline (TMTV0) computed on PET may improve the evaluation of tumour burden. To explore the clinical usefulness of TMTV0, we compared the prognostic value of TMTV0, tumour bulk and interim PET response in a retrospective single-centre study.
Methods
From 2007 to 2010, 59 consecutive patients with a first diagnosis of HL were treated in our institution. PET was done at baseline (PET0) and after two cycles of chemotherapy (PET2), and treatment was not modified according to the PET2 result. TMTV0 was measured with a semiautomatic method using a 41 % SUVmax threshold. SUVmax reduction between PET0 and PET2 (ΔSUVmaxPET0-2) was also computed. Based on ROC analysis, patients …
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S Kanoun, C Rossi, A Berriolo-Riedinger… - European journal of nuclear medicine and molecular …, 2014