作者
Olivier Humbert, Alina Berriolo-Riedinger, Alexandre Cochet, Mélanie Gauthier, Céline Charon-Barra, Séverine Guiu, Isabelle Desmoulins, Michel Toubeau, Inna Dygai-Cochet, Charles Coutant, Pierre Fumoleau, François Brunotte
发表日期
2014/3
期刊
European journal of nuclear medicine and molecular imaging
卷号
41
页码范围
416-427
出版商
Springer Berlin Heidelberg
简介
Purpose
The objective of this study was to evaluate, in the luminal human epidermal growth factor receptor 2 (HER2)-negative breast cancer subtype, the prognostic value of tumour glucose metabolism at baseline and of its early changes during neoadjuvant chemotherapy (NAC).
Methods
This prospective study included 61 women with hormone-sensitive HER2-negative breast cancer treated with NAC. 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET) was performed at baseline. Hepatic activity was used as a reference to distinguish between low metabolic and hypermetabolic tumours. In hypermetabolic tumours, a PET exam was repeated after the first course of NAC. The relative change in the maximum standardized uptake value of the tumour (∆SUV) was calculated.
Results
Nineteen women had …
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O Humbert, A Berriolo-Riedinger, A Cochet, M Gauthier… - European journal of nuclear medicine and molecular …, 2014