作者
Olivier Humbert, Alina Berriolo-Riedinger, Jean-Marc Riedinger, Bruno Coudert, Laurent Arnould, Alexandre Cochet, Catherine Loustalot, Pierre Fumoleau, François Brunotte
发表日期
2012/10/1
期刊
Annals of oncology
卷号
23
期号
10
页码范围
2572-2577
出版商
Elsevier
简介
Background
The aim of this study is to evaluate the impact of the different breast cancer subtypes on the tumor 18F-FDG uptake at baseline and on its changes after the first course of neoadjuvant chemotherapy (NAC).
Patients and Methods
One hundred and fifteen women with newly diagnosed, large or locally advanced breast cancer undergoing NAC were included. Estrogen receptor (ER), progesterone receptor (PR) and HER2 status were used to define three major tumor subtypes: triple negative (TN) (ER-/PR-/HER2-), luminal (ER+ and/or PR+; HER2-) and HER2 positive (HER2+). Using Fluorine-18 fluorodeoxyglucose positron emission tomography, the tumoral standard uptake value (SUV) maximal index was measured at baseline and just before the second course of NAC.
Results
TN tumors presented the highest baseline SUV (11.3 ± 8.5; P < 0.0001). The decrease of SUV after the first course of NAC (ΔSUV …
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