作者
James E Galagan, Sarah E Calvo, Katherine A Borkovich, Eric U Selker, Nick D Read, David Jaffe, William FitzHugh, Li-Jun Ma, Serge Smirnov, Seth Purcell, Bushra Rehman, Timothy Elkins, Reinhard Engels, Shunguang Wang, Cydney B Nielsen, Jonathan Butler, Matthew Endrizzi, Dayong Qui, Peter Ianakiev, Deborah Bell-Pedersen, Mary Anne Nelson, Margaret Werner-Washburne, Claude P Selitrennikoff, John A Kinsey, Edward L Braun, Alex Zelter, Ulrich Schulte, Gregory O Kothe, Gregory Jedd, Werner Mewes, Chuck Staben, Edward Marcotte, David Greenberg, Alice Roy, Karen Foley, Jerome Naylor, Nicole Stange-Thomann, Robert Barrett, Sante Gnerre, Michael Kamal, Manolis Kamvysselis, Evan Mauceli, Cord Bielke, Stephen Rudd, Dmitrij Frishman, Svetlana Krystofova, Carolyn Rasmussen, Robert L Metzenberg, David D Perkins, Scott Kroken, Carlo Cogoni, Giuseppe Macino, David Catcheside, Weixi Li, Robert J Pratt, Stephen A Osmani, Colin PC DeSouza, Louise Glass, Marc J Orbach, J Andrew Berglund, Rodger Voelker, Oded Yarden, Michael Plamann, Stephan Seiler, Jay Dunlap, Alan Radford, Rodolfo Aramayo, Donald O Natvig, Lisa A Alex, Gertrud Mannhaupt, Daniel J Ebbole, Michael Freitag, Ian Paulsen, Matthew S Sachs, Eric S Lander, Chad Nusbaum, Bruce Birren
发表日期
2003/4
期刊
Nature
卷号
422
期号
6934
页码范围
859-868
出版商
Nature Publishing Group
简介
Neurospora crassa is a central organism in the history of twentieth-century genetics, biochemistry and molecular biology. Here, we report a high-quality draft sequence of the N. crassa genome. The approximately 40-megabase genome encodes about 10,000 protein-coding genes—more than twice as many as in the fission yeast Schizosaccharomyces pombe and only about 25% fewer than in the fruitfly Drosophila melanogaster. Analysis of the gene set yields insights into unexpected aspects of Neurospora biology including the identification of genes potentially associated with red light photobiology, genes implicated in secondary metabolism, and important differences in Ca 2+ signalling as compared with plants and animals. Neurospora possesses the widest array of genome defence mechanisms known for any eukaryotic organism, including a process unique to fungi called repeat-induced point mutation (RIP …
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JE Galagan, SE Calvo, KA Borkovich, EU Selker… - Nature, 2003