作者
Nishita Tripathi, Yeonjung Jo, Abhishek Tripathi, Nicolas Sayegh, Haoran Li, Roberto Nussenzveig, Benjamin Haaland, Vinay M Thomas, Sumati Gupta, Benjamin L Maughan, Umang Swami, Sumanta K Pal, Petros Grivas, Neeraj Agarwal, Deepika Sirohi
发表日期
2022/11/1
期刊
Urologic Oncology: Seminars and Original Investigations
卷号
40
期号
11
页码范围
493. e1-493. e7
出版商
Elsevier
简介
Background
Urothelial carcinoma with squamous differentiation (UCS) is the most common variant differentiation of urothelial carcinoma (UC). Although treatment is usually similar to pure UC, there is paucity of data regarding its genomic landscape and putative molecular drivers. In this study, we compared the mutational profile of tumors with UCS and UC histology.
Methods
In this IRB-approved retrospective study, patients with advanced UCS and UC undergoing tumor based comprehensive genomic profiling from a CLIA-certified laboratory were included. An independent genitourinary pathologist reviewed all cases. Patients were determined to have UCS based on presence of any component of squamous differentiation. Patients with UC having any other secondary histology variant were excluded. Genes with alterations (GA) in less than 5% of patients and variants of unknown significance were excluded from …
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N Tripathi, Y Jo, A Tripathi, N Sayegh, H Li… - Urologic Oncology: Seminars and Original …, 2022