作者
Georges Gebrael, Nicolas Sayegh, Vinay Mathew Thomas, Beverly Chigarira, Nishita Tripathi, Yeon Jung Jo, Haoran Li, Kamal Kant Sahu, Ayana Srivastava, Taylor McFarland, Benjamin L Maughan, Umang Swami, Neeraj Agarwal
发表日期
2024/6
期刊
Prostate Cancer and Prostatic Diseases
卷号
27
期号
2
页码范围
279-282
出版商
Nature Publishing Group UK
简介
Introduction
In patients with metastatic hormone-sensitive prostate cancer (mHSPC) undergoing intensified androgen deprivation therapy (ADT), not achieving an optimal PSA response, defined as PSA nadir >0.2 ng/ml (PSAsubOR) has been associated with worse survival outcomes in clinical trials (1)(10)(11). Here, we externally evaluate, the impact of optimal PSA response on survival outcomes in these patients and provide absolute PFS and OS measures in those with PSAsubOR in the context of ADT intensification in real world setting.
Methods
In this retrospective study, all consecutive patients with mHSPC who underwent intensified ADT treated at our institution, and whose outcomes data were available, were included. We classified patients based on their PSA nadir on treatment: those with a on treatment PSAOR (PSA nadir ≤0.2 ng/ml) versus PSAsubOR.
Results
A total of 205 patients were eligible: 136 (66 …
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G Gebrael, N Sayegh, VM Thomas, B Chigarira… - Prostate Cancer and Prostatic Diseases, 2024