作者
Joseph E Tonna, Craig H Selzman, Jason A Bartos, Angela P Presson, Zhining Ou, Yeonjung Jo, Lance B Becker, Scott T Youngquist, Ravi R Thiagarajan, M Austin Johnson, Sung-Min Cho, Peter Rycus, Heather T Keenan
发表日期
2022/5/1
期刊
Resuscitation
卷号
174
页码范围
53-61
出版商
Elsevier
简介
Research question
Given the relative independence of ventilator settings from gas exchange and plasticity of blood gas values during extracorporeal cardiopulmonary resuscitation (ECPR), do mechanical ventilation parameters and blood gas values influence survival?
Methods
Observational cohort study of 7488 adult patients with ECPR from the Extracorporeal Life Support Organization (ELSO) Registry. We performed case-mix adjustment for severity of illness and patient type using generalized estimating equation logistic regression to determine factors associated with hospital survival accounting for clustering by center, standardizing variables by 1 standard deviation (SD) of their values. We examined non-linear relationships between ventilatory and blood gas values with hospital survival.
Results
Hospital survival was decreased with higher PaO2 on ECMO (OR 0.69, per 1SD increase [95% CI 0.64, 0.74]; p < 0 …
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JE Tonna, CH Selzman, JA Bartos, AP Presson, Z Ou… - Resuscitation, 2022