作者
Antonio Abbate, Fadi N Salloum, Elena Vecile, Anindita Das, Nicholas N Hoke, Stefania Straino, Giuseppe GL Biondi-Zoccai, Jon-Erik Houser, Ian Z Qureshi, Evan D Ownby, Edoardo Gustini, Luigi M Biasucci, Anna Severino, Maurizio C Capogrossi, George W Vetrovec, Filippo Crea, Alfonso Baldi, Rakesh C Kukreja, Aldo Dobrina
发表日期
2008/5/20
期刊
Circulation
卷号
117
期号
20
页码范围
2670-2683
出版商
Lippincott Williams & Wilkins
简介
Background— Experimental interleukin-1 receptor antagonist gene overexpression has shown that interleukin-1 receptor antagonist is cardioprotective during global cardiac ischemia. The aim of the present study was to test the impact of an exogenous recombinant human interleukin-1 receptor antagonist (anakinra) in experimental acute myocardial infarction.
Methods and Results— Two animal studies were conducted: one of immediate anakinra administration during ischemia in the mouse and one of delayed anakinra administration 24 hours after ischemia in the rat. Seventy-eight Institute of Cancer Research mice and 20 Wistar rats underwent surgical coronary artery ligation (or sham operation) and were treated with either anakinra 1 mg/kg or NaCl 0.9% (saline). Treatment was administered during surgery and then daily for 6 doses in the mice and starting on day 2 daily for 5 doses in the rats. Twenty-eight …
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A Abbate, FN Salloum, E Vecile, A Das, NN Hoke… - Circulation, 2008