作者
Emilie S Fritsch, Christophe D Chabbert, Bernd Klaus, Lars M Steinmetz
发表日期
2014/10/1
期刊
Genetics
卷号
198
期号
2
页码范围
755-771
出版商
Oxford University Press
简介
In eukaryotic cells, the production of cellular energy requires close interplay between nuclear and mitochondrial genomes. The mitochondrial genome is essential in that it encodes several genes involved in oxidative phosphorylation. Each cell contains several mitochondrial genome copies and mitochondrial DNA recombination is a widespread process occurring in plants, fungi, protists, and invertebrates. Saccharomyces cerevisiae has proved to be an excellent model to dissect mitochondrial biology. Several studies have focused on DNA recombination in this organelle, yet mostly relied on reporter genes or artificial systems. However, no complete mitochondrial recombination map has been released for any eukaryote so far. In the present work, we sequenced pools of diploids originating from a cross between two different S. cerevisiae strains to detect recombination events. This strategy allowed us to …
学术搜索中的文章
ES Fritsch, CD Chabbert, B Klaus, LM Steinmetz - Genetics, 2014