作者
Yan Gao, Yitao Mao, Shanhong Lu, Lei Tan, Guo Li, Juan Chen, Donghai Huang, Xin Zhang, Yuanzheng Qiu, Yong Liu
发表日期
2021/12
期刊
Head & Neck
卷号
43
期号
12
页码范围
3730-3742
出版商
John Wiley & Sons, Inc.
简介
Background
To establish a radiomics nomogram for survival prediction and determine if genomic data were related to radiomics signature in advanced nasopharyngeal carcinoma (NPC).
Methods
Radiomics features were extracted from contrast‐enhanced T1‐weighted images (CE‐T1WI) in 316 patients. A progression‐free survival (PFS) nomogram was developed and validated by the combination of the radiomics signature and clinicopathologic factors. Whole transcriptomics sequencing was performed in pretreatment tumor samples; correlation of gene expression and radiomics signature was further investigated.
Results
A 24‐feature‐combined radiomics signature was highly correlated with PFS; its integration with clinical predictors showed good prediction performance in the training and the validation cohort (C‐index: 0.80 and 0.73). A significant correlation was observed between certain gene expression …
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Y Gao, Y Mao, S Lu, L Tan, G Li, J Chen, D Huang… - Head & Neck, 2021