作者
Garth F Essig Jr, Kyle Porter, David Schneider, Arpaia Debora, Susan C Lindsey, Giulia Busonero, Daniel Fineberg, Barbara Fruci, Kristien Boelaert, Johannes W Smit, Johannes Arnoldus Anthonius Meijer, Leonidas Duntas, Neil Sharma, Giuseppe Costante, Sebastiano Filetti, Rebecca S Sippel, Bernadette Biondi, Duncan J Topliss, Furio Pacini, Rui MB Maciel, Patrick C Walz, Richard T Kloos
发表日期
2013/11/1
期刊
Endocrine Practice
卷号
19
期号
6
页码范围
920-927
出版商
Elsevier
简介
Objectives
To evaluate the diagnostic accuracy of fine-needle aspiration biopsy (FNAB) to preoperatively diagnose medullary thyroid cancer (MTC) among multiple international centers and evaluate how the cytological diagnosis alone could impact patient management.
Methods
We performed a retrospective chart review of sporadic MTC (sMTC) patients from 12 institutions over the last 29 years. FNAB cytology results were compared to final pathologic diagnoses to calculate FNAB sensitivity. To evaluate the impact of cytology sensitivity for MTC according to current practice and to avoid confounding results by local treatment protocols, changes in treatment patterns over time, and the influence of ancillary findings (e.g., serum calcitonin), therapeutic interventions based on FNAB cytology alone were projected into 1 of 4 treatment categories: total thyroidectomy (TT) and central neck dissection (CND), TT without CND …
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GF Essig Jr, K Porter, D Schneider, A Debora… - Endocrine Practice, 2013