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In the United States and worldwide, billions of dollars have been spent to develop behavioral, biobehavioral, and biomedical interventions (hereafter referred to simply as interventions) to prevent and treat health problems, promote health and wellbeing, prevent violence, improve learning, promote academic achievement, and generally improve the human condition. Numerous interventions are in use that are successful in the sense that they have demonstrated a statistically and clinically significant effect in a randomized controlled trial (RCT). However, many are less successful in terms of progress toward solving problems. In fact, after decades of research, as a society we continue to struggle with the very issues these interventions have been designed to ameliorate. Only very slow progress is being made in many areas; in some, the problem continues to worsen. Let us consider two examples in the public health …