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In this chapter, we advocate for an approach in which a pre-study is integrated in research into group interactions: Mixed Structural Group Interaction Analysis. The aim of the pre-study is to collect data on latent social relationships that informs the data collection, analysis, and interpretation of the main research. Based on theories and empirical insight from social network analysis, we address the “why” and “how” of this argument. Specifically, we show how a relational pre-study could be integrated with group interaction data collection and analysis in a development-type mixed-methods research design.