作者
Ting Wang, Shangfeng Wang, Zhiyong Liu, Zuyang He, Peng Yu, Mengyao Zhao, Hongxin Zhang, Lingfei Lu, Zhengxin Wang, Ziyu Wang, Weian Zhang, Yong Fan, Caixia Sun, Dongyuan Zhao, Weimin Liu, Jean-Claude G Bünzli, Fan Zhang
发表日期
2021/11
期刊
Nature Materials
卷号
20
期号
11
页码范围
1571-1578
出版商
Nature Publishing Group UK
简介
Spectrally distinct fluorophores are desired for multiplexed bioimaging. In particular, monitoring biological processes in living mammals needs fluorophores that operate in the ‘tissue-transparent’ near-infrared (NIR) window, that is, between 700 and 1,700 nm. Here we report a fluorophore system based on molecular erbium(III)–bacteriochlorin complexes with large Stokes shift (>750 nm) and narrowband NIR-to-NIR downconversion spectra (full-width at half-maximum ≤ 32 nm). We have found that the fast (2 × 109 s–¹) and near-unity energy transfer from bacteriochlorin triplets to the erbium(III) 4I13/2 level overcomes the notorious vibrational overtones quenching, resulting in bright and long-lived (1.73 μs) 1,530 nm luminescence in water. We demonstrate the excitation/emission-multiplexed capability of the complexes in the visualization of dynamic circulatory and metabolic processes in living mice, and …
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T Wang, S Wang, Z Liu, Z He, P Yu, M Zhao, H Zhang… - Nature Materials, 2021