作者
Chenzhi Yao, Ying Chen, Mengyao Zhao, Shangfeng Wang, Bin Wu, Yiwei Yang, Dongrui Yin, Peng Yu, Hongxin Zhang, Fan Zhang
发表日期
2022/1/26
期刊
Angewandte Chemie
卷号
134
期号
5
页码范围
e202114273
简介
Early detection of kidney disease is of vital importance due to its current prevalence worldwide. Fluorescence imaging, especially in the second near‐infrared window (NIR‐II) has been regarded as a promising technique for the early diagnosis of kidney disease due to the superior resolution and sensitivity. However, the reported NIR‐II organic renal‐clearable probes are hampered by their low brightness (ϵmaxΦf>1000 nm<10 M−1 cm−1) and limited blood circulation time (t1/2<2 h), which impede the targeted imaging performance. Herein, we develop the aza‐boron‐dipyrromethene (aza‐BODIPY) brush macromolecular probes (Fudan BDIPY Probes (FBP 912)) with high brightness (ϵmaxΦf>1000 nm≈60 M−1 cm−1), which is about 10‐fold higher than that of previously reported NIR‐II renal‐clearable organic probes. FBP 912 exhibits an average diameter of ≈4 nm and high renal clearance efficiency …
学术搜索中的文章
C Yao, Y Chen, M Zhao, S Wang, B Wu, Y Yang, D Yin… - Angewandte Chemie, 2022