作者
Meghan E McGarry, Elizabeth Castellanos, Neeta Thakur, Sam S Oh, Celeste Eng, Adam Davis, Kelley Meade, Michael A LeNoir, Pedro C Avila, Harold J Farber, Denise Serebrisky, Emerita Brigino-Buenaventura, William Rodriguez-Cintron, Rajesh Kumar, Kirsten Bibbins-Domingo, Shannon M Thyne, Saunak Sen, Jose R Rodriguez-Santana, Luisa N Borrell, Esteban G Burchard
发表日期
2015/6/1
期刊
Chest
卷号
147
期号
6
页码范围
1591-1598
出版商
Elsevier
简介
BACKGROUND
Obesity is associated with poor asthma control, increased asthma morbidity, and decreased response to inhaled corticosteroids. We hypothesized that obesity would be associated with decreased bronchodilator responsiveness in children and adolescents with asthma. In addition, we hypothesized that subjects who were obese and unresponsive to bronchodilator would have worse asthma control and would require more asthma controller medications.
METHODS
In the Study of African Americans, Asthma, Genes, and Environments (SAGE II) and the Genes-environments and Admixture in Latino Americans (GALA II) study, two identical, parallel, case-control studies of asthma, we examined the association between obesity and bronchodilator response in 2,963 black and Latino subjects enrolled from 2008 to 2013 using multivariable logistic regression. Using bronchodilator responsiveness, we …
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ME McGarry, E Castellanos, N Thakur, SS Oh, C Eng… - Chest, 2015