作者
Evangelos Evangelou, Hanneke J Kerkhof, Unnur Styrkarsdottir, Evangelia E Ntzani, Steffan D Bos, Tonu Esko, Daniel S Evans, Sarah Metrustry, Kalliope Panoutsopoulou, Yolande FM Ramos, Gudmar Thorleifsson, Konstantinos K Tsilidis, Nigel Arden, Nadim Aslam, Nicholas Bellamy, Fraser Birrell, Francisco J Blanco, Andrew Carr, Kay Chapman, Aaron G Day-Williams, Panos Deloukas, Michael Doherty, Gunnar Engström, Hafdis T Helgadottir, Albert Hofman, Thorvaldur Ingvarsson, Helgi Jonsson, Aime Keis, J Christiaan Keurentjes, Margreet Kloppenburg, Penelope A Lind, Andrew McCaskie, Nicholas G Martin, Lili Milani, Grant W Montgomery, Rob GHH Nelissen, Michael C Nevitt, Peter M Nilsson, William ER Ollier, Neeta Parimi, Ashok Rai, Stuart H Ralston, Mike R Reed, Jose A Riancho, Fernando Rivadeneira, Cristina Rodriguez-Fontenla, Lorraine Southam, Unnur Thorsteinsdottir, Aspasia Tsezou, Gillian A Wallis, J Mark Wilkinson, Antonio Gonzalez, Nancy E Lane, L Stefan Lohmander, John Loughlin, Andres Metspalu, Andre G Uitterlinden, Ingileif Jonsdottir, Kari Stefansson, P Eline Slagboom, Eleftheria Zeggini, Ingrid Meulenbelt, John PA Ioannidis, Tim D Spector, Joyce BJ van Meurs, Ana M Valdes, arcOGEN Consortium
发表日期
2014/12/1
来源
Annals of the rheumatic diseases
卷号
73
期号
12
页码范围
2130-2136
出版商
BMJ Publishing Group Ltd
简介
Objectives
Osteoarthritis (OA) is the most common form of arthritis with a clear genetic component. To identify novel loci associated with hip OA we performed a meta-analysis of genome-wide association studies (GWAS) on European subjects.
Methods
We performed a two-stage meta-analysis on more than 78 000 participants. In stage 1, we synthesised data from eight GWAS whereas data from 10 centres were used for ‘in silico’ or ‘de novo’ replication. Besides the main analysis, a stratified by sex analysis was performed to detect possible sex-specific signals. Meta-analysis was performed using inverse-variance fixed effects models. A random effects approach was also used.
Results
We accumulated 11 277 cases of radiographic and symptomatic hip OA. We prioritised eight single nucleotide polymorphism (SNPs) for follow-up in the discovery stage (4349 OA cases); five from the combined analysis, two male …
学术搜索中的文章
E Evangelou, HJ Kerkhof, U Styrkarsdottir, EE Ntzani… - Annals of the rheumatic diseases, 2014