作者
Anne Jarstein Skjulsvik, Hans Kristian Bø, Asgeir Store Jakola, Erik Magnus Berntsen, Lars Eirik Bø, Ingerid Reinertsen, Kristin Smistad Myrmel, Kristin Sjåvik, Kristin Åberg, Thomas Berg, Hong Yan Dai, Roar Kloster, Sverre Helge Torp, Ole Solheim
发表日期
2020/3
期刊
Journal of Neuro-oncology
卷号
147
页码范围
147-157
出版商
Springer US
简介
Introduction
According to the stem cell theory, two neurogenic niches in the adult human brain may harbor cells that initiate the formation of gliomas: The larger subventricular zone (SVZ) and the subgranular zone (SGZ) in the hippocampus. We wanted to explore whether defining molecular markers in low-grade gliomas (LGG; WHO grade II) are related to distance to the neurogenic niches.
Methods
Patients treated at two Norwegian university hospitals with population-based referral were included. Eligible patients had histopathological verified supratentorial low-grade glioma. IDH mutational status and 1p19q co-deletion status was retrospectively assessed. 159 patients were included, and semi-automatic tumor segmentation was done from pre-treatment T2-weighted (T2W) or Fluid-Attenuated Inversion Recovery (FLAIR) images. 3D maps showing the …
学术搜索中的文章
AJ Skjulsvik, HK Bø, AS Jakola, EM Berntsen, LE Bø… - Journal of Neuro-oncology, 2020