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Biological systems have evolved haloperoxidase (HaloPO) enzymes to catalyze the oxidation of chloride, bromide and iodide by hydrogen peroxide. Recent reviews have been published that deal with various aspects and activity of these enzymes. 1–11 Three classes of haloperoxidases have been identified. The first is a class of enzymes found in bacteria without a prosthetic group. 12, 13 The second is hemecontaining peroxidases such as chloroperoxidase (CPO) first discovered in the marine fungus Caldariomyces fumago in 1966, 14 myeroperoxidase, eosinophil peroxidase and lactoperoxidase from mammalian systems. 15 The third class of haloperoxidases is vanadium-containing peroxidases that require a vanadate ion (VO4 23). Vanadium peroxidase was fist discovered in the brown alga Ascophyllum nodosum in 1984 16 but since then it has also been found in lichen Xanthoria parietina 17 and in fungi …