作者
Suleyman Gulsuner, Tom Walsh, Amanda C Watts, Ming K Lee, Anne M Thornton, Silvia Casadei, Caitlin Rippey, Hashem Shahin, David Braff, Kristin S Cadenhead, Monica E Calkins, Dorcas J Dobie, Robert Freedman, Michael Green, Tiffany Greenwood, Raquel E Gur, Ruben C Gur, Laura Lazzeroni, Gregory Light, Keith Nuechterlein, Ann Olincy, Al Radant, Amrita Ray, Nik Schork, Larry J Seidman, Larry Siever, Jeremy Silverman, William S Stone, Catherine Sugar, Neal Swerdlow, Debby Tsuang, Ming Tsuang, Bruce Turetsky, Tolulope Aduroja, Trina Allen, L Diane Bradford, Bernie Devlin, Neil B Edwards, Rohan Ganguli, Rodney CP Go, Joseph Kwentus, Adrienne C Lahti, Paul Lyons, Kim Mathos, Roberta May, Steve McLeod-Bryant, Joseph P McEvoy, Laura Montgomery-Barefield, Vishwajit L Nimgaonkar, Judith O’Jile, Al Santos, Robert M Savage, Charles L Swanson, William Wilson, Neal R Swerdlow, David L Braff, Mary-Claire King, Jon M McClellan
发表日期
2013/8/1
期刊
Cell
卷号
154
期号
3
页码范围
518-529
出版商
Elsevier
简介
Genes disrupted in schizophrenia may be revealed by de novo mutations in affected persons from otherwise healthy families. Furthermore, during normal brain development, genes are expressed in patterns specific to developmental stage and neuroanatomical structure. We identified de novo mutations in persons with schizophrenia and then mapped the responsible genes onto transcriptome profiles of normal human brain tissues from age 13 weeks gestation to adulthood. In the dorsolateral and ventrolateral prefrontal cortex during fetal development, genes harboring damaging de novo mutations in schizophrenia formed a network significantly enriched for transcriptional coexpression and protein interaction. The 50 genes in the network function in neuronal migration, synaptic transmission, signaling, transcriptional regulation, and transport. These results suggest that disruptions of fetal prefrontal cortical …
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S Gulsuner, T Walsh, AC Watts, MK Lee, AM Thornton… - Cell, 2013