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There is a clear need for broad‐spectrum cholinesterase reactivators (active against a multitude of organophosphorus ester enzyme inhibitors) with a higher efficacy than pralidoxime. The purpose of the study was to quantify in vivo the extent of oxime‐conferred protection, using methyl‐paraoxon [dimethyl p‐nitrophenyl phosphate; (methyl‐POX)] as a cholinesterase inhibitor.

There were seven groups of six rats in each cycle of the experiment. Group 1 (G1) received 2 µmol methyl‐POX (≈ LD₅₀), the other groups (G2‐7) received 2 µmol methyl‐POX + one of the six reactivators. The animals were monitored for 48 h and the time of mortality was recorded. The procedure was repeated six times. All substances were applied i.p. The experiments were repeated using 3 and 5 µmol methyl‐POX. Mortality data were compared and hazards ratios (relative risks) ranked using the Cox proportional hazards model with …