作者
Murat Oz, Dietrich E Lorke, Mohammed Hasan, George A Petroianu
发表日期
2011/1
来源
Medicinal research reviews
卷号
31
期号
1
页码范围
93-117
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
Methylene Blue (MB), following its introduction to biology in the 19th century by Ehrlich, has found uses in various areas of medicine and biology. At present, MB is the first line of treatment in methemoglobinemias, is used frequently in the treatment of ifosfamide‐induced encephalopathy, and is routinely employed as a diagnostic tool in surgical procedures. Furthermore, recent studies suggest that MB has beneficial effects in Alzheimer's disease and memory improvement. Although the modulation of the cGMP pathway is considered the most significant effect of MB, mediating its pharmacological actions, recent studies indicate that it has multiple cellular and molecular targets. In the majority of cases, biological effects and clinical applications of MB are dictated by its unique physicochemical properties including its planar structure, redox chemistry, ionic charges, and light spectrum characteristics. In this review article …
引用总数
学术搜索中的文章
M Oz, DE Lorke, M Hasan, GA Petroianu - Medicinal research reviews, 2011