作者
Kathryn A Ellis, Ashley I Bush, David Darby, Daniela De Fazio, Jonathan Foster, Peter Hudson, Nicola T Lautenschlager, Nat Lenzo, Ralph N Martins, Paul Maruff, Colin Masters, Andrew Milner, Kerryn Pike, Christopher Rowe, Greg Savage, Cassandra Szoeke, Kevin Taddei, Victor Villemagne, Michael Woodward, David Ames, AIBL Research Group
发表日期
2009/8
期刊
International psychogeriatrics
卷号
21
期号
4
页码范围
672-687
出版商
Cambridge University Press
简介
Background
The Australian Imaging, Biomarkers and Lifestyle (AIBL) flagship study of aging aimed to recruit 1000 individuals aged over 60 to assist with prospective research into Alzheimer's disease (AD). This paper describes the recruitment of the cohort and gives information about the study methodology, baseline demography, diagnoses, medical comorbidities, medication use, and cognitive function of the participants.
Methods
Volunteers underwent a screening interview, had comprehensive cognitive testing, gave 80 ml of blood, and completed health and lifestyle questionnaires. One quarter of the sample also underwent amyloid PET brain imaging with Pittsburgh compound B (PiB PET) and MRI brain imaging, and a subgroup of 10% had ActiGraph activity monitoring and body composition scanning.
Results
A total of 1166 volunteers were recruited, 54 of whom were excluded from further study due to …
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KA Ellis, AI Bush, D Darby, D De Fazio, J Foster… - International psychogeriatrics, 2009