查看文章

A novel hybrid nanofibrous scaffold prepared with chitosan [containing 1.2 wt% polyethylene oxide (PEO)] and bioactive glass (BG) was fabricated by an electrospinning technique. The morphological and physicochemical properties of scaffolds were studied by scanning electron microscopy (SEM) and spectroscopy. The measurements of tensile strength and water-contact angles suggested that the incorporation of BG into the nanofibers improves the mechanical properties and hydrophilicity of the scaffolds. Biomineralization of the nanofibers was evaluated by soaking them in simulated body fluid (SBF), and the formation of hydroxycarbonate apatite (HCA) layer was determined by EDX and FE-SEM. The results showed that BG-containing nanofibers could induce the formation of HCA on the surface of the composite after 14 days of immersion in SBF. In vitro-cell viability of human mesenchymal stromal cells …