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In recent decades, research on health care design and planning has highlighted the strong relationship between environmental characteristics and human health. According to a patient-centered model, the focus on the hospital environment is important in reducing the negative effects of hospitalization on the patient, especially in the case of children. In a hospital Pediatric Unit, a pictorial intervention, characterized by natural landscapes with cartoon characters, was introduced. The study sought to evaluate the effects of this intervention on the affective qualities attributed to the hospital environment by parents whose children were hospitalized; our main hypothesis was that the pictorial intervention would benefit parents, enhancing the positive and reducing the negative affective perception of the hospital environment. A total of 502 parents of admitted children aged 0–11 completed a questionnaire to describe the …