作者
Matthias J Koepp, Lorenzo Caciagli, Ronit M Pressler, Klaus Lehnertz, Sándor Beniczky
发表日期
2016/1/1
来源
The Lancet Neurology
卷号
15
期号
1
页码范围
92-105
出版商
Elsevier
简介
Epileptic seizures are generally unpredictable and arise spontaneously. Patients often report non-specific triggers such as stress or sleep deprivation, but only rarely do seizures occur as a reflex event, in which they are objectively and consistently modulated, precipitated, or inhibited by external sensory stimuli or specific cognitive processes. The seizures triggered by such stimuli and processes in susceptible individuals can have different latencies. Once seizure-suppressing mechanisms fail and a critical mass (the so-called tipping point) of cortical activation is reached, reflex seizures stereotypically manifest with common motor features independent of the physiological network involved. The complexity of stimuli increases from simple sensory to complex cognitive-emotional with increasing age of onset. The topography of physiological networks involved follows the posterior-to-anterior trajectory of brain …
引用总数
2016201720182019202020212022202320241310111613151195
学术搜索中的文章
MJ Koepp, L Caciagli, RM Pressler, K Lehnertz… - The Lancet Neurology, 2016