查看文章

The clinical application of G‐CSF is broadening. In addition to treating neutropenia and in bone marrow transplants, it is now being considered for functional recovery after myocardial infarction and stroke. It is thus very important that the effects of extended G‐CSF administration on the skeleton are investigated. To simulate this potential clinical use of G‐CSF in postmyocardial infarction or cerebral vascular accident, a 2‐week course of administration was selected. Ten C57BL/6 mice at 22 weeks of age were given intraperitoneal injection of saline, and another nine of the same age were given G‐CSF. Four weeks later, femurs were harvested and three‐point‐bend tests were performed until fracture. From the load‐displacement curve recorded during the test, the stiffness, Young's modulus, fracture strength of the bone, fracture energy, and the total energy to break the femur were determined. The test data show that …