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OBJECTIVES:

Fecal microbiota transplant (FMT) is a highly efficacious treatment for recurrent or refractoryClostridium difficileinfection (CDI); however, 10–20% of patients fail to achieve cure after a single FMT. The aim of this study was to identify risk factors associated with FMT failure and to develop and validate a prediction model for FMT failure.

METHODS:

Patient characteristics, CDI history, FMT characteristics, and outcomes data for patients treated between 2011 and 2015 at three academic tertiary referral centers were prospectively collected. Early FMT failure was defined as non-response or recurrence of diarrhea associated with positive stoolC. difficiletoxin or PCR within 1 month of FMT. Late FMT failure was defined as recurrence of diarrhea associated with positive stoolC. difficiletoxin or PCR between 1 and 3 months of the FMT. Patient data from two centers were used to determine independent predictors of …