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Purpose: To review the current medical literature regarding the safety of statin use and the potential side effects.

Methods: Major statin trials and review articles on the safety of statins were identified in a search of the MEDLINE database from 1980 to 2014 limited to English articles.

Results: Myalgia is the most common side effect with documented rates from 1-10%. Rhabdomyolysis is the most serious adverse effect from statin use and is very rare (less than 0.1%). The most common risk factors for statin related myopathy include hypothyroidism, polypharmacy and alcohol abuse. Derangement in liver function tests is common affecting up to 1% of patients, however the clinical significance of this is unknown. Statin drugs are diabetogenic and the risk appears to increase in those on higher doses. Statins have not been proven to increase the risk of malignancy, dementia, mood disorders and acute interstitial nephritis …