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Resistance to all the classes of anti‐nematodal drugs like the benzimidazoles, cholinergic agonists and avermectins, has now been recorded in parasites of animals and/or humans. The development of novel anthelmintics is an urgent and imperative need. Receptors of nematode neuropeptides have been suggested to be suitable target sites for novel anthelmintic drugs.

To investigate the effect of AF2 on calcium‐currents in Ascaris suum somatic muscle cells we employed the two‐micropipette current–clamp and voltage–clamp techniques and a brief application of AF2.

Here we report the isolation of voltage‐activated, transient, inward calcium currents. These currents are similar in characteristics to Caenorhabditis elegans UNC‐2 type currents, non‐L‐type calcium currents. Following a 2‐minute application of 1 μM AF2, there was a significant long …