作者
Erola Pairo-Castineira, Sara Clohisey, Lucija Klaric, Andrew D Bretherick, Konrad Rawlik, Dorota Pasko, Susan Walker, Nick Parkinson, Max Head Fourman, Clark D Russell, James Furniss, Anne Richmond, Elvina Gountouna, Nicola Wrobel, David Harrison, Bo Wang, Yang Wu, Alison Meynert, Fiona Griffiths, Wilna Oosthuyzen, Athanasios Kousathanas, Loukas Moutsianas, Zhijian Yang, Ranran Zhai, Chenqing Zheng, Graeme Grimes, Rupert Beale, Jonathan Millar, Barbara Shih, Sean Keating, Marie Zechner, Chris Haley, David J Porteous, Caroline Hayward, Jian Yang, Julian Knight, Charlotte Summers, Manu Shankar-Hari, Paul Klenerman, Lance Turtle, Antonia Ho, Shona C Moore, Charles Hinds, Peter Horby, Alistair Nichol, David Maslove, Lowell Ling, Danny McAuley, Hugh Montgomery, Timothy Walsh, Alexandre C Pereira, Alessandra Renieri, GenOMICC Investigators GenOMICC Consortium, GenOMICC co-investigators Millar Johnny 1 Nichol Alistair 22 Walsh Tim 11 Shankar-Hari Manu 16 Ponting Chris 2, Data analysis team, Guy’s & St Thomas’ Hospital, London, UK Shankar-Hari M. 41 Ostermann M. 41 Campos S. 41 Bociek A. 41 Lim R. 41 Grau N. 41 Jones TO 41 Whitton C. 41 Marotti M. 41 Arbane G. 41, James Cook University Hospital, Middlesburgh, UK Bonner S. 42 Hugill K. 42 Reid J. 42, Royal Liverpool University Hospital, Liverpool, UK Welters I. 43 Waugh V. 43 Williams K. 43 Shaw D. 43 Roman J. Fernandez 43 Martinez M. Lopez 43 Johnson E. 43 Waite A. 43 Johnston B. 43 Hamilton D. 43 Mulla S. 43, King’s College Hospital, London, UK McPhail M. 44 Smith J. 44, Royal Infirmary of Edinburgh, Edinburgh, UK Baillie JK 1 2 11 Barclay L. 45 Hope D. 45 McCulloch C. 45 McQuillan L. 45 Clark S. 45 Singleton J. 45 Priestley K. 45 Rea N. 45 Callaghan M. 45 Campbell R. 45 Andrew G. 45 Marshall L. 45, John Radcliffe Hospital, Oxford, UK McKechnie S. 46 Hutton P. 46 Bashyal A. 46 Davidson N. 46, Addenbrooke’s Hospital, Cambridge, UK Summers C. 47 Polgarova P. 47 Stroud K. 47 Pathan N. 47 Elston K. 47 Agrawal S. 47, Morriston Hospital, Swansea, UK Battle C. 48 Newey L. 48 Rees T. 48 Harford R. 48 Brinkworth E. 48 Williams M. 48 Murphy C. 48, Ashford & St Peter’s Hospital, Surrey, UK White I. 49 Croft M. 49, Royal Stoke University Hospital, Staffordshire, UK Bandla N. 50 Gellamucho M. 50 Tomlinson J. 50 Turner H. 50 Davies M. 50 Quinn A. 50 Hussain I. 50 Thompson C. 50 Parker H. 50 Bradley R. 50 Griffiths R. 50, Queen Elizabeth Hospital, Birmingham, UK Scriven J. 51 Nilsson A. 51 Bates M. 51 Dasgin J. 51 Gill J. 51, Glasgow Royal Infirmary, Glasgow, UK Puxty A. 52 Cathcart S. 52 Salutous D. 52 Turner L. 52 Duffy K. 52 Puxty K. 52, Kingston Hospital, Surrey, UK Joseph A. 53 Herdman-Grant R. 53 Simms R. 53 Swain A. 53 Naranjo A. 53 Crowe R. 53 Sollesta K. 53 Loveridge A. 53 Baptista D. 53 Morino E. 53, Tunbridge Wells Hospital & Maidstone Hospital, Kent, UK Davey M. 54 Golden D. 54 Jones J. 54, North Middlesex University Hospital NHS Trust, London, UK Moreno Cuesta J. 55 Haldeos A. 55 Bakthavatsalam D. 55 Vincent R. 55 Elhassan M. 55 Xavier K. 55 Ganesan A. 55 Purohit D. 55 Abdelrazik M. 55, Bradford Royal Infirmary, Bradford, UK Morgan J. 56 Akeroyd L. 56 Bano S. 56 Lawton T. 56 Warren D. 56 Bromley M. 56 Sellick K. 56 Gurr L. 56 Wilkinson B. 56 Nagarajan V. 56 Szedlak P. 56, Blackpool Victoria Hospital, Blackpool, UK Cupitt J. 57 Stoddard E. 57 Benham L. 57 Preston S. 57 Laha S. 57 Slawson N. 57 Bradshaw Z. 57 Brown J. 57 Caswell M. 57 Melling S. 57, Countess of Chester Hospital, Chester, UK Bamford P. 58 Faulkner M. 58 Cawley K. 58 Jeffrey H. 58 London E. 58 Sainsbury H. 58 Nagra I. 58 Nasir F. 58 Dunmore C. 58 Jones R. 58 Abraheem A. 58 Al-Moasseb M. 58 Girach R. 58, Wythenshawe Hospital, Manchester, UK Padden G. 59 Egan J. 59 Brantwood C. 59 Alexander P. 59 Bradley-Potts J. 59 Allen S. 59 Felton T. 59, Good Hope Hospital, Birmingham, UK Scriven J. 61 Willis H. 61 Hopkins B. 61 Thrasyvoulou L. 61, Stepping Hill Hospital, Stockport, UK Jackson M. 62 Zaki A. 62 Tibke C. 62 Bennett S. 62 Woodyatt W. 62 Kent A. 62 Goodwin E. 62, Manchester Royal Infirmary, Manchester, UK Brandwood C. 63 Clark R. 63 Smith L. 63, Queen Elizabeth University Hospital, Glasgow, UK Henderson S. 65 Sim M. 65 Kennedy-Hay S. 65 McParland C. 65 Rooney L. 65 Baxter N. 65, Queen Alexandra Hospital, Portsmouth, UK Pogson D. 66 Rose S. 66 Daly Z. 66 Brimfield L. 66, BHRUT (Barking Havering)-Queens Hospital & King George Hospital, Essex, UK Phull MK 67 Hussain M. 67 Pogreban T. 67 Rosaroso L. 67 Salciute E. 67 Grauslyte L. 67, University College Hospital, London, UK Brealey D. 68 Raith E. 68 MacCallum N. 68 Bercades G. 68 Hass I. 68 Smyth D. 68 Reyes A. 68 Martir G. 68, Royal Victoria Infirmary, Newcastle Upon Tyne, UK Clement ID 69 Webster K. 69 Hays C. 69 Gulati A. 69, Royal Oldham Hospital, Manchester, UK Drummond A. 72 Tully R. 72 Dearden J. 72 Philbin J. 72 Munt S. 72 Rishton C. 72 O’Connor G. 72 Mulcahy M. 72 Dobson E. 72 Cuttler J. 72 Edward M. 72, Pinderfields General Hospital, Wakefield, UK Norris J. 73 Hanson K. 73 Poole A. 73 Rose A. 73 Sloan B. 73 Buckley S. 73 Brooke H. 73 Smithson E. 73 Charlesworth R. 73 Sandhu R. 73 Thirumaran M. 73 Wagstaff V. 73 Suarez J. Cebrian 73, Basildon Hospital, Basildon, UK Kaliappan A. 74 Vertue M. 74 Nicholson A. 74 Riches J. 74 Solesbury A. 74 Kittridge L. 74 Forsey M. 74 Maloney G. 74, University Hospital of Wales, Cardiff, UK Cole J. 75 Davies M. 75 Davies R. 75 Hill H. 75 Thomas E. 75 Williams A. 75 Duffin D. 75 Player B. 75, Broomfield Hospital, Chelmsford, UK Radhakrishnan J. 76 Gibson S. 76 Lyle A. 76 McNeela F. 76, Royal Brompton Hospital, London, UK Patel B. 77 Gummadi M. 77 Sloane G. 77 Dormand N. 77 Salmi S. 77 Farzad Z. 77 Cristiano D. 77 Liyanage K. 77 Thwaites V. 77 Varghese M. 77, Nottingham University Hospital, Nottingham, UK Meredith M. 78, Royal Hampshire County Hospital, Hampshire, UK Watson G. 80 Martin J. 80 Bevan E. 80 Brown C. Wrey 80 Trodd D. 80, Queens Hospital Burton, Burton-On-Trent, UK English K. 81 Bell G. 81 Wilcox L. 81 Katary A. 81, New Cross Hospital, Wolverhampton, UK Gopal S. 82 Lake V. 82 Harris N. 82 Metherell S. 82 Radford E. 82, Heartlands Hospital, Birmingham, UK Scriven J. 83 Moore F. 83 Bancroft H. 83 Daglish J. 83 Sangombe M. 83 Carmody M. 83 Rhodes J. 83 Bellamy M. 83, Walsall Manor Hospital, Walsall, UK Garg A. 84 Kuravi A. 84 Virgilio E. 84 Ranga P. 84 Butler J. 84 Botfield L. 84 Dexter C. 84 Fletcher J. 84, Stoke Mandeville Hospital, Buckinghamshire, UK Shanmugasundaram P. 85 Hambrook G. 85 Burn I. 85 Manso K. 85 Thornton D. 85 Tebbutt J. 85 Penn R. 85, Sandwell General Hospital, Birmingham, UK Hulme J. 86 Hussain S. 86 Maqsood Z. 86 Joseph S. 86 Colley J. 86 Hayes A. 86 Ahmed C. 86 Haq R. 86 Clamp S. 86 Kumar R. 86 Purewal M. 86 Baines B. 86, Royal Berkshire NHS Foundation Trust, Berkshire, UK Frise M. 87 Jacques N. 87 Coles H. 87 Caterson J. 87 Rai S. 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Sera 93, King’s Mill Hospital, Nottingham, UK Paul P. 94 Gill M. 94 Wynter I. 94 Ratnam V. 94 Shelton S. 94, Fairfield General Hospital, Bury, UK Naisbitt J. 95 Melville J. 95, Western General Hospital, Edinburgh, UK Baruah R. 96 Morrison S. 96, Northwick Park Hospital, London, UK McGregor A. 97 Parris V. 97 Mpelembue M. 97 Srikaran S. 97 Dennis C. 97 Sukha A. 97, Royal Preston Hospital, Preston, UK Williams A. 98 Verlander M. 98, Royal Derby Hospital, Derby, UK Holding K. 99 Riches K. 99 Downes C. 99 Swan C. 99, Sunderland Royal Hospital, Sunderland, UK Rostron A. 100 Roy A. 100 Woods L. 100 Cornell S. 100 Wakinshaw F. 100, Royal Surrey County Hospital, Guildford, UK Creagh-Brown B. 101 Blackman H. 101 Salberg A. 101 Smith E. 101 Donlon S. 101 Mtuwa S. 101 Michalak-Glinska N. 101 Stone S. 101 Beazley C. 101 Pristopan V. 101, Derriford Hospital, Plymouth, UK Nikitas N. 102 Lankester L. 102 Wells C. 102, Croydon University Hospital, Croydon, UK Raj AS 103 Fletcher K. 103 Khade R. 103 Tsinaslanidis G. 103, Victoria Hospital, Kirkcaldy, UK MacMahon M. 104 Fowler S. 104 McGregor A. 104 Coventry T. 104, Milton Keynes University Hospital, Milton Keynes, UK Stewart R. 105 Wren L. 105 Mwaura E. 105 Mew L. 105 Rose A. 105 Scaletta D. 105 Williams F. 105, Barnsley Hospital, Barnsley, UK Inweregbu K. 106 Nicholson A. 106 Lancaster N. 106 Cunningham M. 106 Daniels A. 106 Harrison L. 106 Hope S. 106 Jones S. 106 Crew A. 106 Wray G. 106 Matthews J. 106 Crawley R. 106, York Hospital, York, UK Carter J. 107 Birkinshaw I. 107 Ingham J. 107 Scott Z. 107 Pearson H. 107 Howard K. 107 Joy R. 107 Roche S. 107, University Hospital of North Tees, Stockton on Tees, UK Clark M. 108 Purvis S. 108, University Hospital Wishaw, Wishaw, UK Morrison A. 109 Strachan D. 109 Taylor M. 109 Clements S. 109 Black K. 109, Whittington Hospital, London, UK Parmar C. 110 Altabaibeh A. 110 Simpson K. 110 Mostoles L. 110 Gilbert K. 110 Ma L. 110 Alvaro A. 110, Southmead Hospital, Bristol, UK Thomas M. 111 Faulkner B. 111 Worner R. 111 Hayes K. 111 Gendall E. 111 Blakemore H. 111 Borislavova B. 111 Goff E. 111, Royal Papworth Hospital, Cambridge, UK Vuylsteke A. 112 Mwaura L. 112 Zamikula J. 112 Garner L. 112 Mitchell A. 112 Mepham S. 112 Cagova L. 112 Fofano A. 112 Holcombe H. 112 Praman K. 112, Royal Gwent Hospital, Newport, UK Szakmany T. 113 Heron AE 113 Cherian S. 113 Cutler S. 113 Roynon-Reed A. 113, Norfolk & Norwich University Hospital (NNUH), Norwich, UK Randell G. 114 Convery K. 114 Stammers K. 114 Fottrell-Gould D. 114 Hudig L. 114 Keshet-Price J. 114, Airedale General Hospital, Keighley, UK Hairsine B. 116 Dooks E. 116 Farquhar F. 116 Packham S. 116 Bates H. 116 McParland C. 116 Armstrong L. 116, Aberdeen Royal Infirmary, Aberdeen, UK Kaye C. 117 Allan A. 117 Medhora J. 117 Liew J. 117 Botello A. 117 Anderson F. 117, Southampton General Hospital, Southampton, UK Cusack R. 118 Golding H. 118 Prager K. 118 Williams T. 118 Leggett S. 118 Golder K. 118 Male M. 118 Jones O. 118 Criste K. 118 Marani M. 118, Russell’s Hall Hospital, Dudley, UK Anumakonda V. 119 Amin V. 119 Karthik K. 119 Kausar R. 119 Anastasescu E. 119 Reid K. 119 Smith M. 119, Rotherham General Hospital, Rotherham, UK Hormis A. 120 Walker R. 120 Collier D. 120, North Manchester General Hospital, Manchester, UK Duncan T. 121 Uriel A. 121 Ustianowski A. 121 T-Michael H. 121 Bruce M. 121 Connolly K. 121 Smith K. 121, Basingstoke & North Hampshire Hospital, Basingstoke, UK Partridge R. 122 Griffin D. 122 Mupudzi M. 122 Muchenje N. 122, Royal Free Hospital, London, UK Martin D. 123 Filipe H. 123 Eastgate C. 123 Jackson C. 123, Hull Royal Infirmary, Hull, UK Gratrix A. 124 Foster L. 124 Martinson V. 124 Stones E. 124 Abernathy Caroline 124 Parkinson P. 124, Harefield Hospital, London, UK Reed A. 125 Prendergast C. 125 Rogers P. 125 Woodruff M. 125 Shokkar R. 125 Kaul S. 125 Barron A. 125 Collins C. 125, Chesterfield Royal Hospital Foundation Trust, Chesterfield, UK Beavis S. 126 Whileman A. 126 Dale K. 126 Hawes J. 126 Pritchard K. 126 Gascoyne R. 126 Stevenson L. 126, Barnet Hospital, London, UK Jha R. 127 Lim L. 127 Krishnamurthy V. 127, Aintree University Hospital, Liverpool, UK Parker R. 128 Turner-Bone I. 128 Wilding L. 128 Reddy A. 128, St James’s University Hospital & Leeds General Infirmary, Leeds, UK Whiteley S. 129 Wilby E. 129 Howcroft C. 129 Aspinwall A. 129 Charlton S. 129 Ogg B. 129, Glan Clwyd Hospital, Bodelwyddan, UK Menzies D. 130 Pugh R. 130 Allan E. 130 Lean R. 130 Davies F. 130 Easton J. 130 Qiu X. 130 Kumar S. 130 Darlington K. 130, University Hospital Crosshouse, Kilmarnock, UK Houston G. 131 O’Brien P. 131 Geary T. 131 Allan J. 131 Meikle A. 131, Royal Bolton Hospital, Bolton, UK Hughes G. 132 Balasubramaniam M. 132 Latham S. 132 McKenna E. 132 Flanagan R. 132, Princess of Wales Hospital, Llantrisant, UK Sathe S. 133 Davies E. 133 Roche L. 133
发表日期
2021/3/4
期刊
Nature
卷号
591
期号
7848
页码范围
92-98
出版商
Nature Publishing Group UK
简介
Host-mediated lung inflammation is present, and drives mortality, in the critical illness caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with critical illness may identify mechanistic targets for therapeutic development. Here we report the results of the GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2,244 critically ill patients with COVID-19 from 208 UK intensive care units. We have identified and replicated the following new genome-wide significant associations: on chromosome 12q24.13 (rs10735079, P = 1.65 × 10−8) in a gene cluster that encodes antiviral restriction enzyme activators (OAS1, OAS2 and OAS3); on chromosome 19p13.2 (rs74956615, P = 2.3 × 10−8) near the gene that encodes tyrosine kinase 2 (TYK2); on chromosome 19p13.3 (rs2109069, P = 3.98 ×  10−12) within the gene that encodes dipeptidyl peptidase 9 (DPP9); and on …
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E Pairo-Castineira, S Clohisey, L Klaric, AD Bretherick… - Nature, 2021