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Organ loss and failure is one of the most critical issues facing the healthcare industry in developed nations. The shortage of available organ donors has driven the growth and expansion of the field of tissue engineering as a means of developing replacement tissues and organs [1, 2] including the liver.[3] Microfabrication and bio-microelectromechanical system (bio-MEMS) technology is an attractive tool for developing tissue-engineering systems because of the improved spatial resolutions over traditional scaffold fabrication techniques such as casting and porogen leaching,[4] gas foaming,[5] and three-dimensional printing.[6] Polymer scaffolds replicamolded on micromachined silicon substrates can achieve feature resolutions of less than 10 μm,[7] the same lengthscale of mammalian cells. Microfluidic bioreactors have been both fabricated and seeded with a variety of cell types, including endothelial cells [7–10 …